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Telling powerful stories in hourlong episodes, TLC follows medical journeys of morbidly obese people as they attempt to save their own lives. The featured individuals - each weighing more than 600 pounds confront lifelong emotional and physical struggles as they make the courageous decision to undergo high-risk gastric bypass surgery. In addition to drastically changing their appearances, they hope to reclaim their independence, mend relationships with friends and family, and renew their feelings of self-worth.